Route six is located in the Southwest section of the town. The route is bordered on the North by Main Street and extends from Watertown Square to the Waltham line. To the East, the route is bordered by Watertown Square and extends up Galen Street to the Newton line. To the South, the route is bordered by Boyd Street, running diagonally West towards Watertown Street.
On the westernmost edge of the route, is Lyons Court at the Newton Line. At this point, the route runs diagonally northeast through the Stop and Shop plaza out to the Charles River, goes West to Bridge Street and turns North where it connects with Pleasant Street. The route is primarily commercial with a substantial residential mix throughout.